Early Postoperative Nociceptive Threshold and Production of Brain-Derived Neurotrophic Factor Induced by Plantar Incision Are Not Influenced with Minocycline in a Rat: Role of Spinal Microglia

Background: Brain-derived neurotrophic factor (BDNF) from spinal microglia is crucial for aberrant nociceptive signaling in several pathological pain conditions, including postoperative pain.We assess the contribution of spinal microglial activation and associated BDNF overexpression to the early post-incisional nociceptive threshold.Methods: Male

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Modeling social transmission dynamics of unhealthy behaviors for evaluating prevention and treatment interventions on childhood obesity.

Research evidence indicates that obesity has spread through social networks, but lever points for interventions based on overlapping networks are not well studied.The objective of our research was to construct and parameterize a system dynamics model of the social transmission BRAZIL ACAI of behaviors through adult and youth influence in order to e

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